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KMID : 0377619720220020179
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Korean Jungang Medical Journal
1972 Volume.22 No. 2 p.179 ~ p.184
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Changes in the Tuberculin Allergy During the Course of Measles
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白哲弘/Paek, Chul Hong
金容彦/徐相夏/琴東爀/Kim, Yong Eon/Suh, Sang Ha/Kum, Dong Hyuck
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Abstract
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The author made observations in three baby-homes where the measles prevailed from the beginning of March 1964 to the end of June 1969.
Observation was made on 118 infants whose tuberculin reaction had already shown positive (20 -cases naturally converted, 98 cases converted after BCG vaccination).
Old tuberculin diluted 2, 000 times, made by the National Institute of Health, was used under the currently widely applied Mantoux intracutaneous method on children during measles to observe the change of tuberculin allergy.
The results obtained were as follows:
1) Both children with regular measles and children with measles modified by adult plasma showed decrease of the diameter of the redness 3 to 5 days before the appearance of the rash, and most children from 2 days before and 5 days after appearance the rash showed negative reaction most marked. The decrease in tuberculin allergy was noticed during the eruptive period. No change was specially noticed during the incubation period except for 1 negative case.
2) The length of time elapsing before the tuberculin test turned from negative to positive was an average of 16. 2 days in the group of regular measles and in the group of measles modified by adult plasma, which was intended for passive immunization the time lapse was average of 13 days. Statistically such difference in lapse of time between the two groups was insignificant.
3) In children having measles with pneumonia, the length of time elapsing before the tuberculin test turned from negative to positive averaged 17. 2 days. This means although the case with pneumonia appears longer than the case of measles without pneumonia, there is no significant difference statistically.
4) No significant difference was noticed in the average lengths between the naturally converted case of tuberculin reaction and the positive case turning from negative to positive after BCG vaccination.
5) Repeated tuberculin test every 3 days for 6 weeks produced no case in which the decrease in the tuberculin reaction due to desensitization.
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